Marcasiano founded her design company in 1977 after graduating from Parsons School of Design and was honored with the Cartier, DuPont, Cutty Sark and Wool Knit Awards. Her design work is currently centered around costumes for dance, film, theater and for Grammy Award winning singer and Unicef Ambassador Angelique Kidjo. In 2007 Marcasiano created the Made with Love Project, dedicated to supporting women's crafts, and children's aid programs, in Brazil and Africa. A recurring theme in Marcasiano’s work is the culture of Africa and the African Diaspora. Marcasiano serves as Director of Strategic Partnerships to Cinema Tropical, a nonprofit promoting Latin American cinema in the US and as Director of Development to IMPACT Repertory Theater, a program for under-resourced youth in Harlem. In Spring of 2019 Marcasiano received her Masters Degree from NYU Gallatin for her Thesis "UpScale: Scaling Up Nonprofit Capacity". Her Masters studies focused on the intersection of Art, Nonprofits and Social Change.